Duanbekova G.B.

Abstract. One of frequent complications of acute exogenous poisonings is the toxic hepatopathy. Entering of toxic substances into an organism and their subsequent metabolization result in increased formation of free radicals. The identification of the HOL role when acute poisoning leads to the search of new effective drugs with antioxidatic properties. The purpose of our researches is studying of antioxidant properties “Essentiale” and new pharmacological substance amidophosphanata citizin (AFC). All experimental procedures were carried out according to the requirements of GLP (Good Laboratory Practice-appropriate laboratory practice). Acute toxic hepatitis was caused by intraperitoneal introduction of 40% oil ССL₄ solution, in the dose of 0,2 ml / 100,0 once. By results of the researches acute poisoning with four-chloride Carbonium resulted in toxic hepatitis. The introduction of the tested pharmacological compound amidophosphanata citizin reduced the increased activity of AlаT, AsаT, amount of blood total bilirubin (TB), as well as the growth of DC (level the diene conjugates in the experienced group 2,7 times lower than in the group of comparison, and 3,8 times more than in the control one) and limited accumulation of SB. Introduction of paracetamol in the increased dose causes toxic hepatitis of the tested animals.
Key words: Amidophosphanat citizina,  hepatoprotector,  “Essentiale”,  hyperoxide oxidation of lipids,  four-chloride Carbonium, hepatopathy