МРНТИ 34.25.23, 34.25.37                                                                                  №4 (2020г.)

Turmagambetova A.S., Bogoyavlenskiy A.P., Sokolova N.S., Omirtaeva E.S., Berezin   V.E.

To this day, influenza and other acute respiratory viral infections pose a serious global health problem, causing epidemics and pandemics accompanied by high mortality rates. The ability of influenza to change leads to the emergence of new strains that are resistant to existing antinfluenza drugs, rapidly spreading across all continents. In this regard, the development of the pharmaceutical industry and the creation of new effective drugs against dangerous and widespread viral infections is one of the priority tasks that faces any nation. The aim of the work was to study the antiviral action of mangosteen and gartanin against human and bird influenza viruses. It was revealed that in the dose range from 0.025 ug/ml
to 1.25 ug/ml mangosteen demonstrated pronounced antiviral properties comparable with the antiviral activity of Tamiflu. Gartanin showed a rather high antiviral action against epidemiologically significant strains of the human influenza virus.
Keywords: xanthone, antiviral activity, mangosteen, gartanin.