Plant terpenoids as a basis for the development of new antivirals

№3 (2018)

 

Turmagambetova A.S., Zaitseva I.A., Omirtaeva E.S., Sokolova N.S., Bogoyavlenskiy A.P., Atazhanova G.A., Mukusheva G.K., Adekenov S.M., Berezin V.E.

 

Terpenoids the group of secondary metabolites of higher plants, which has no analogues in terms of the diversity of structural types and biological role in the regulation of life processes of living organisms. This large group of substances, numbering more than 23 thousand compounds with established chemical structure, surpasses in the number of representatives all other classes of natural compounds. The presence of antiviral activity in various classes of terpenoids indicates the prospects of their study for use as antiviral agents. The antiviral activity of some mono-, sesquiterpenes and triterpene saponins was investigated in the work. It was shown that all studied groups of terpenoids can be considered as promising antiviral agents on the model of influenza virus with the antigenic formula H7N1 and H3N2.
Keywords: influenza virus, terpenoids, antiviral activity

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