МРНТИ 34.39.03, 76.29.39

№2-2024

PDF

https://doi.org/10.53939/1560-5655_2024_2_106

Nuralin R. Sh., Nuraly D.R., Ekibaev T.R., Ashimov N.T., Sinyavskii Yu.A.

Abstract. This article presents modern ideas about the study of the efficacy and safety of topical application of a hybrid biodegradable bioengineered construct based on carboxymethylcellulose with spheroids containing bacteriocins from broth cultures of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Escherichia coli atque etiam Pseudomonas aeruginosa in the complex treatment of diabetic foot syndrome. A prospective study of 89 patients with diabetic foot syndrome aged 25 to 74 years was carried out on the basis of the NCC
“Diabetic Foot”, Almaty. The control group consisted of 25 patients aged 26 to 74 years. All patients of the main and control groups received conventional treatment for diabetic foot syndrome. Thus, as a result of studying the local application of a hybrid biodegradable bioengineered construct based on carboxymethylcellulose with spheroids containing bacteriocins from broth cultures of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Escherichia coli atque etiam Pseudomonas aeruginosa in combination with complex treatment of diabetic
foot syndrome, its safety and efficacy were shown, which is also confirmed by the studies of foreign authors.
Key words: hybrid biodegradable bioengineered construct, diabetes mellitus, diabetic foot, broth culture bacteriocins, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes, Enterococcus faecalis, Staphylococcus aureus.

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