Cell technologies in the treatment of critical lower limb ischemia in diabetes mellitus

МРНТИ 34.39.03, 76.29.39

№2-2024

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https://doi.org/10.53939/1560-5655_2024_2_90

Nuralin R. Sh., Nuraly D.R., Ekibaev T.R., Ashimov N.T., Yessimsiitova Z.B.

Abstract. A multicenter prospective cohort study of 24 patients with stage III-IV DUNK was conducted. after percutaneous transluminal angioplasty (PTA) of the main arteries of the lower extremities, 17 patients had trophic lesions of the lower extremities of grade 2-3 according to Wagner. In the postoperative period from 10 to 45 days, autocytotherapy was carried out with autologous mononuclear cells (AMC) of the bone marrow preconditioned with recombinant human erythropoietin (rEPO) in the area of damage to the great vessels of the lower extremities. After
autocytotherapy with AMK pEPO, there was a significant increase in TcpO2 by 54.5%, complete healing of wound defects in 92.3% of patients, and a decrease in the number of restenoses and relapses of ulcers.
Key words: diabetes mellitus, angiopathy of the lower extremities, diabetic foot, ulcer healing, diabetic angiopathy, mononuclear cells.

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